Hemoglobin LeporeBoston in Two Iranian Families

Hemoglobin Lepore,,,. in Two Iranian Families

L EPORE HEMOGLOBINS are the result of unequal crossing over between structural genes coding for #{244} and f3 polypeptide chains of human hemoglobin during melosis. The abnormal polypeptide chain #{244} 3 produced after this crossing over has part of the 5 chain at its N terminus, and the remaining part is similar to the i chain.’ The point of fusion of the two polypeptide chains and the propor...

Molecular and hematologic analysis of hemoglobin Q-Iran and hemoglobin Setif in Iranian families.

BACKGROUND Single nucleotide mutations in alpha1 or alpha2 genes produce abnormal alpha-chain hemoglobins. Hemoglobin Q disorders including hemoglobin Q-Iran, hemoglobin Q-Thailand, and hemoglobin Q-India are important hemoglobin variants. Herein, we report on the presence and hematologic and molecular features of hemoglobin Q-Iran [alpha75 (EF4) Asp-->His] in 20 members of 11 families includin...

Hemoglobin D Los Angeles in Two Caucasian Families: Hemoglobin SD Disease and Hemoglobin D Thalassemia

11 EMOGLOBIN D LOS ANGELES, a2,82121g1m,l (Or D Punjab) is one of I I the more common hemoglobin variants, since it occurs in about 3 per cent of the Sikhs of the Punjab2 and sporadically in other ethnic groups, particularly those that have had considerable contact with India. In electrophoresis and chromatography, this variant is indistinguishable from hemoglobin S; however, it lacks the insol...

Hemoglobin D Los Angeles in two Caucasian families: hemoglobin SD disease and hemoglobin D thalassemia.

11 EMOGLOBIN D LOS ANGELES, a2,82121g1m,l (Or D Punjab) is one of I I the more common hemoglobin variants, since it occurs in about 3 per cent of the Sikhs of the Punjab2 and sporadically in other ethnic groups, particularly those that have had considerable contact with India. In electrophoresis and chromatography, this variant is indistinguishable from hemoglobin S; however, it lacks the insol...

Violence in Iranian Families